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Difference between vitamin d2 and d3

There are two forms of vitamin D one is vitamin D2 and other is D3. Now we can see some difference between them.

Difference between Vitamin D2 and D3 : 

  • Vitamin D2 named ergocalciferol is commonly found in foods while vitamin D3 named cholecalciferol is commonly made by the body naturally when the skin is exposed to the sun.
  • Vitamin D3 is more natural and easier for the body to absorb than D2.
  • Most experts currently believe that the best form of vitamin D supplement to take is vitamin D3.
  • Vitamin D3 is more readily metabolized into a bioactive form of D that is easily converted to its hormone form in the kidneys.
  • Vitamin D2 is broken down by the body into different substances and it can be very harmful to the body while vitamin D3 is broken down by the body into a substance called calcitriol, which actually has very important cancer-fighting properties.
  • The D2 form of the vitamin has a shorter shelf life compared to the D3 form.
  • You can get vitamin D from fortified foods or as pills. However, vitamin D3 is only available in the form of pills or in liquids. 
  • Supplements for both two vitamins are sourced differently.

Summary :

Ergocalciferol (vitamin D2) and Cholecalciferol (vitamin D3) are not bioequivalent and should not be considered interchangeable. But based on pharmacokinetic studies and limited clinical evidence, cholecalciferol is preferred over ergocalciferol. 
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