Definition : It is a common inflammatory disease of pilosebaceous follicles in which the pilosebaceous follicles become oversensitive to a normal level of testosterone. Cause : Androgens Follicular keratinisation Hereditary Propionic bacterium acnes Immunological factor Environmental factor Exacerbating factor : Peak severity of acne is in the late teenage years but acne may persist into the 3rd decade and beyond particularly in a female. Factors : Acne occurs with stress Premenstrual period With aggressive acne or recalcitrant acne, the cause is virilising syndrome in female, acromegaly, Occupational exposure to an agent. A drug like steroids, hormones, anti-epileptic drugs, Iodine. Genetic & hormonal factor plays an important role. Pathogenetic factor : Increase sebum excretion: Clear relation between severity of acne & sebum excretion. Main determinants of sebum excretion are hormonal accounting for the onset of acne in t
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